Bcl3 12051
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| Gene ID: | 12051 |
| Gene symbol: | bcl3 |
| Gene Description: | b-cell leukemia/lymphoma 3 |
| Aliases: | AI528691; Bcl-3 |
| Human Ortholog Gene ID: | [602] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | Transcription Factor Binding: tf co-factor binding |
| Homolog Cluster(s): | 12051; 109181 |
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [1501714] | TF PPI | Other | Medium | "We show here that the proto-oncogene bcl-3 [...] encodes a protein that functions as an I kappa B-like molecule for native NF-kappa B but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-kappa B dimers by contracting the conserved dimerization domain of NF-kappa B." | Jared Roach |
| Additional Reviewer Comments: |
Reviewer: Jared Roach From the human EntrezGene entry: "This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers." [By Wyeth Wasserman]:A protein subject to interpretation of definition? This co-factor holds a DNA binding TF in the cytoplasm. Limit to candidate status as the protein itself does not enter the nucleus and therefore could be considered a part of the signal transduction pathway. After further reading, it should be listed as TF gene as it directly interacts with a DNA binding TF to repress transcription |
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| Gene description | b-cell leukemia/lymphoma 3 + |
| Gene id | 12,051 + |
| Gene judgment | TF Gene + |
| Gene symbol | bcl3 +, AI528691 +, and Bcl-3 + |
| Gene taxonomy | Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 12,051 +, and 109,181 + |
