Atm 11920
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| Gene ID: | 11920 |
| Gene symbol: | atm |
| Gene Description: | ataxia telangiectasia mutated homolog (human) |
| Aliases: | AI256621; C030026E19Rik |
| Human Ortholog Gene ID: | [472] |
| Reviewer Judgement: | TF Gene Candidate |
| Functional Classification: | Transcription Factor Binding: tf co-factor binding |
| Homolog Cluster(s): | 11920 |
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [12496286] | Co-activation; DNA Binding | Mouse | Medium | In cerebral, cerebellar, and hepatic tissue from ATM (-/-) double knockout mice, using EMSA the DNA-binding activity of transcription factor AP-1 was found to be increased relative to the equivalent tissues from ATM (+/+) mice.
In cerebellum from ATM (-/-) double knockout mice, through immunoblotting of nuclear extracts protein expression of transcription factors c-fos and c-jun was increased relative to equivalent tissues from ATM (+/+). In cerebrum from ATM (-/-) double knockout mice, through immunoblotting of nuclear extracts protein expression of transcription factors c-fos was increased relative to equivalent tissues from ATM (+/+). | Stuart Lithwick |
| [16461339] | DNA Binding | Human | Strong | Through serial fractionation of human Raji cells, it was determined that association of ATM with chromatin increases after exposure to ionizing radiation. | Stuart Lithwick |
| [16644862] | Transactivation | Mouse | Medium | In calvarial osteoblasts from a ATM (-/-) double knockout mouse, using semi-quantitative RT-PCR a marked decrease in the expression level of osterix, a transcription factor critical for osteoblast differentiation, was observed, while the expression level of other similar transcription factors remained constant. | Stuart Lithwick |
| Additional Reviewer Comments: |
Reviewer: Stuart Lithwick ATM is likely a negative regulator of other transcription factors. EMSA assays indicate that association of transcription factor AP-1 with DNA is increased in ATM double-knockout mice relative to wild type. As well, increased mRNA expression of transcription factor osterix, and increased protein expression of transcription factors c-fos and c-jun is observed in ATM double knockout mice relative to wild type. Interaction of ATM with chromatin is observed through the fractionation of Raji cells, but only in the context of DNA repair, after exposure to ionizing radiation. It looks as though it gets to DNA by binding to double-strand break binding proteins (PMID 15758953) WWW. |
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| Gene description | ataxia telangiectasia mutated homolog (human) + |
| Gene id | 11,920 + |
| Gene judgment | TF Gene Candidate + |
| Gene symbol | atm +, AI256621 +, and C030026E19Rik + |
| Gene taxonomy | Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 11,920 + |
