Atf7ip 54343
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| Gene ID: | 54343 |
| Gene symbol: | atf7ip |
| Gene Description: | activating transcription factor 7 interacting protein |
| Aliases: | 2610204M12Rik; AM; Mcaf1 |
| Human Ortholog Gene ID: | [55729] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | Transcription Factor Binding: tf co-factor binding |
| Homolog Cluster(s): | 54343 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [10777215] | Co-activation; TF PPI | Mouse | Weak | yeast 2-hybrid screen with ATFa pulls down this protein; subsequent co-localization screen shows they are in the same place in cells; ATPase activity measured | Wyeth Wasserman |
| [14536086] | Co-activation; TF PPI | Human | Medium | ESET/SETDB1 is a histone methyltransferase (HMTase). Here, we show that SETDB1 tightly associates with the human homolog of mAM.
promoter H3-K9 trimethylation causes transcriptional repression; mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1 | Wyeth Wasserman |
| Additional Reviewer Comments: |
Reviewer: Wyeth Wasserman aka mAM (mouse ATFa-associated Modulator) It colocalizes and interacts with ATFa in mammalian cells, contains a bipartite nuclear localization signal and possesses an ATPase activity. PMID 10777215 atp-ase activity; colocalization with atfa; Y2H interaction with ATFa |
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Facts about Atf7ip 54343RDF feed
| Gene description | activating transcription factor 7 interacting protein + |
| Gene id | 54,343 + |
| Gene judgment | TF Gene + |
| Gene symbol | atf7ip +, 2610204M12Rik +, AM +, and Mcaf1 + |
| Gene taxonomy | Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 54,343 + |
