Atf7 223922
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| Gene ID: | 223922 |
| Gene symbol: | atf7 |
| Gene Description: | activating transcription factor 7 |
| Aliases: | 1110012F10Rik; 9430065F09Rik; AI549878; C130020M04Rik; MGC31554 |
| Human Ortholog Gene ID: | [11016] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: sequence-specific |
| DBD Protein Group Classification: | Zipper-Type Group |
| DBD Protein Group/Family Classification: | Zipper-Type Group / Leucine Zipper Family |
| Homolog Cluster(s): | 107503 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [11278933] | DNA Binding | Mouse | Strong | EMSA assays show that ATF-7 can bind to CRE elements. Co-immunoprecipitation experiments show that ATF-7 also binds to PRL-1 and that this interaction allows PRL-1 to dephosphorylate ATF-7 | Sarav Sundararajan |
| [15735663] | Transactivation | Human | Strong | Reporter assays show that the GAL4(DBD)-ATF-7 fusion can transactivate the UAS-luciferase construct and that this transactivation is mediated through interactions between ATF-7 and hsTAF12. | Sarav Sundararajan |
| [1694576] | DNA Binding | Human | Strong | By screening a HeLa cell cDNA library using an adenovirus ATF-binding sequence as the probe, the authors isolated cDNAs encoding ATF7, which they called ATFA, and a splice variant. | Gwenael Breard |
| [11278933] | DNA Binding | Mouse | Strong | ATF-7 is most closely related to members of the ATF/CREB family of bZIP proteins, with highest homology to ATF-4. ATF-7 homodimers can bind specifically to CRE elements. | Gwenael Breard |
| [15735663] | TF PPI | Human | Strong | Athors show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. In support of this conclusion, chromatin immunoprecipitation experiments confirm the interaction of ATF7 with TAF12 on an ATF7-responsive promoter, in the absence of any artificial overexpression of both proteins. | Gwenael Breard |
| Additional Reviewer Comments: |
Reviewer: Gwenael Breard The ATF7 proteins, which are members of the cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors, display quite versatile properties: they can interact with the adenovirus E1a oncoprotein, mediating part of its transcriptional activity; they heterodimerize with the Jun, Fos or related transcription factors, likely modulating their DNA-binding specificity; they also recruit to the promoter a stress-induced protein kinase (JNK2) and bind TAF12. |
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Facts about Atf7 223922RDF feed
| Gene description | activating transcription factor 7 + |
| Gene id | 223,922 + |
| Gene judgment | TF Gene + |
| Gene symbol | atf7 +, 1110012F10Rik +, 9430065F09Rik +, AI549878 +, C130020M04Rik +, and MGC31554 + |
| Gene taxonomy | DNA-Binding: sequence-specific + |
| Homolog cluster | 107,503 + |
| Protein family | 3 Zipper-Type Group/21 Leucine Zipper Family + |
| Protein group | 3 Zipper-Type Group + |
