Atf4 11911
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| Gene ID: | 11911 |
| Gene symbol: | atf4 |
| Gene Description: | activating transcription factor 4 |
| Aliases: | Atf-4; C/ATF; CREB2; MGC96460; TAXREB67 |
| Human Ortholog Gene ID: | [468] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: sequence-specific |
| DBD Protein Group Classification: | Zipper-Type Group |
| DBD Protein Group/Family Classification: | Zipper-Type Group / Leucine Zipper Family |
| Homolog Cluster(s): | 107503 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [15109498] | Transactivation | Mouse | Medium | Decrease in Osteocalcin expression observed in Atf4-deficient mice using Alcian blue/alizarin red staining over developmental stages. DNA cotransfection experiments demontrate that an Atf4 expression vector increases activity of an Osteocalcin promoter-luciferase chimeric gene. | Debra Fulton |
| [16000305] | Transactivation | Mouse | Strong | ATF4 stimulates the promoter-luciferase reporter gene (contains a single ATF4-binding site (OSE1) and two Runx2-binding sites (OSE2) see PMID: 7891679 ) activity in MC-4 cells. Transfection of C3H10T1/2 cells with expression plasmids and a promoter-luciferase reporter gene demonstrate that ATF4 increases the osteocalcin message level when Runx2 protein is co-expressed. | Debra Fulton |
| Additional Reviewer Comments: |
Reviewer: Debra Fulton DNA cotransfection experiments demontrate that an Atf4 expression vector increases activity of an Osteocalcin promoter-luciferase chimeric gene. ATF4 increases the mouse osteocalcin message level when Runx2 protein is co-expressed. |
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Facts about Atf4 11911RDF feed
| Gene description | activating transcription factor 4 + |
| Gene id | 11,911 + |
| Gene judgment | TF Gene + |
| Gene symbol | atf4 +, Atf-4 +, C/ATF +, CREB2 +, MGC96460 +, and TAXREB67 + |
| Gene taxonomy | DNA-Binding: sequence-specific + |
| Homolog cluster | 107,503 + |
| Protein family | 3 Zipper-Type Group/21 Leucine Zipper Family + |
| Protein group | 3 Zipper-Type Group + |
