Arx 11878
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| Gene ID: | 11878 |
| Gene symbol: | arx |
| Gene Description: | aristaless related homeobox gene (drosophila) |
| Aliases: | |
| Human Ortholog Gene ID: | [170302] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: sequence-specific |
| DBD Protein Group Classification: | Helix-Turn-Helix Group |
| DBD Protein Group/Family Classification: | Helix-Turn-Helix Group / Homeodomain Family |
| Homolog Cluster(s): | 103889 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [15930104] | DNA Binding; Transactivation | Mouse | Medium | Strong evidence that Arx binds to a specific site in Pax4 promoter in south-western, EMSA and chIP experiments.
Weak evidence that Arx might repress Pax4 activity. Arx repress basal reporter activity in gene reporter assay using luciferase reporter constructs containing five copies of its binding site. | Elodie Portales-Casamar |
| Additional Reviewer Comments: |
Reviewer: Elodie Portales-Casamar Strong evidence of DNA specific binding through south-western, EMSA and chIP experiments but poor evidence of transactivation. Only one relevant paper was found. |
| DISCUSSION PAGE link for this gene |
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Facts about Arx 11878RDF feed
| Gene description | aristaless related homeobox gene (drosophila) + |
| Gene id | 11,878 + |
| Gene judgment | TF Gene + |
| Gene symbol | arx + |
| Gene taxonomy | DNA-Binding: sequence-specific + |
| Homolog cluster | 103,889 + |
| Protein family | 1.1 Helix-Turn-Helix Group/2 Homeodomain Family + |
| Protein group | 1.1 Helix-Turn-Helix Group + |
