Arnt2 11864
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| Gene ID: | 11864 |
| Gene symbol: | arnt2 |
| Gene Description: | aryl hydrocarbon receptor nuclear translocator 2 |
| Aliases: | Hif-2b; mKIAA0307 |
| Human Ortholog Gene ID: | [9915] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: sequence-specific |
| DBD Protein Group Classification: | Zipper-Type Group |
| DBD Protein Group/Family Classification: | Zipper-Type Group / Helix-Loop-Helix Family |
| Homolog Cluster(s): | 11622; 15206 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [8657146] | DNA Binding; Transactivation | Mouse | Strong | Performed Gel-shift assays on ARNT2 with a labelled XRE and showed DNA-binding activity. Also showed transactivation using a yeast two-hybrid assay by fusing deletion constructs to the GAL4-DNA binding domain and mapped the activation domain to the C-terminus. | Sarav Sundararajan |
| Additional Reviewer Comments: |
Reviewer: Sarav Sundararajan This gene encodes a sequence-specific transcription factor. Gel shift experiments demonstrated that ARNT2 bound specifically the xenobiotic responsive element (XRE) sequence, while a yeast two-hybrid assay demonstrated transactivation activity. |
| DISCUSSION PAGE link for this gene |
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Facts about Arnt2 11864RDF feed
| Gene description | aryl hydrocarbon receptor nuclear translocator 2 + |
| Gene id | 11,864 + |
| Gene judgment | TF Gene + |
| Gene symbol | arnt2 +, Hif-2b +, and mKIAA0307 + |
| Gene taxonomy | DNA-Binding: sequence-specific + |
| Homolog cluster | 11,622 +, and 15,206 + |
| Protein family | 3 Zipper-Type Group/22 Helix-Loop-Helix Family + |
| Protein group | 3 Zipper-Type Group + |
