Arid1b 239985
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| Gene ID: | 239985 |
| Gene symbol: | arid1b |
| Gene Description: | at rich interactive domain 1b (swi1 like) |
| Aliases: | 8030481M12; 9330189K18Rik; AI836955; Ardi1b; B230217J03Rik; mKIAA1235 |
| Human Ortholog Gene ID: | [57492] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | Transcription Regulatory Activity: heterochromatin interaction/binding;
DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding |
| DBD Protein Group Classification: | Helix-Turn-Helix Group |
| DBD Protein Group/Family Classification: | Helix-Turn-Helix Group / Arid Domain Family |
| Homolog Cluster(s): | 239985 |
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [12200431] | TF PPI | Human | Strong | Mass spectrometric analysis and immunoblotting from HeLa nuclear extracts demonstrate the presence of hOsa2 (ARID1B) in SWI/SNF-A. Co-precipitation studies from C33A cells indicate that hOsa2 associates with BRG1 and hBRM (essential ATPase subunits of SWI/SNF- related complexes) through the C-terminal domain of hOsa. In cultured mammalian T47D cells, hOsa2 stimulates transcription mediated by the steroid hormone receptors. | Amy Ticoll |
| [15170388] | Non-specific DNA; TF PPI | Human | Medium | Immunocomplex analysis in Saos-2 cells provides direct evidence that endogenous ARID1B is associated with SWI/SNF-related complexes. Additional immunocomplex analysis indicates that ARID1B associates with both ATPases (BRG1 and hBRM) of the complex in vivo. Analysis of DNA-binding behaviour in a in a DNA pull-down assay indicates that ARID1B binds DNA in a non-sequence-specific manner. | Amy Ticoll |
| Additional Reviewer Comments: |
Reviewer: Amy Ticoll The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis, and may interact with site-specific transcription factors or other cofactors. Mass spectrometric analysis and immunoblotting demonstrate the presence of ARID1B in SWI/SNF-related complexes. Co-precipitation studies indicate that ARID1B associates with BRG1 and hBRM, essential ATPase subunits of SWI/SNF-related complexes. Analysis of DNA-binding behaviour in a in a DNA pull-down assay indicates that ARID1B binds DNA in a non-sequence-specific manner. ARID1B stimulates transcription mediated by the steroid hormone receptors. |
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| Gene description | at rich interactive domain 1b (swi1 like) + |
| Gene id | 239,985 + |
| Gene judgment | TF Gene + |
| Gene symbol | arid1b +, 8030481M12 +, 9330189K18Rik +, AI836955 +, Ardi1b +, B230217J03Rik +, and mKIAA1235 + |
| Gene taxonomy | Transcription Regulatory Activity: heterochromatin interaction/binding +, DNA-Binding: non-sequence-specific +, and Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 239,985 + |
| Protein family | 1.1 Helix-Turn-Helix Group/109 Arid Domain Family + |
| Protein group | 1.1 Helix-Turn-Helix Group + |
