Arid1a 93760
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| Gene ID: | 93760 |
| Gene symbol: | arid1a |
| Gene Description: | at rich interactive domain 1a (swi1 like) |
| Aliases: | 1110030E03Rik; Osa1; Smarcf1 |
| Human Ortholog Gene ID: | [8289] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: non-sequence-specific |
| DBD Protein Group Classification: | Helix-Turn-Helix Group |
| DBD Protein Group/Family Classification: | Helix-Turn-Helix Group / Arid Domain Family |
| Homolog Cluster(s): | 239985 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [15170388] | Non-specific DNA | Human | Medium | "We have generated monoclonal antibodies specific for either p270 or ARID1B to facilitate the investigation of ARID1B and its potential interaction with human SWI/SNF complexes in vivo. Immunocomplex analysis provides direct evidence that endogenous ARID1B is associated with SWI/SNF-related complexes and indicates that p270 and ARID1B, similar to the ATPase subunits BRG1 and hBRM, are alternative, mutually exclusive subunits of the complexes... ...Analysis of DNA-binding behaviour indicates that ARID1B binds DNA in a non-sequence-specific manner similar to p270 [the authors use p270 as a synonym for ARID1A]." | Jared Roach |
| Additional Reviewer Comments: |
Reviewer: Jared Roach ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin |
| DISCUSSION PAGE link for this gene |
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Facts about Arid1a 93760RDF feed
| Gene description | at rich interactive domain 1a (swi1 like) + |
| Gene id | 93,760 + |
| Gene judgment | TF Gene + |
| Gene symbol | arid1a +, 1110030E03Rik +, Osa1 +, and Smarcf1 + |
| Gene taxonomy | DNA-Binding: non-sequence-specific + |
| Homolog cluster | 239,985 + |
| Protein family | 1.1 Helix-Turn-Helix Group/109 Arid Domain Family + |
| Protein group | 1.1 Helix-Turn-Helix Group + |
