Apex1 11792
From TFCatWiki
External Links
| Gene ID: | 11792 |
| Gene symbol: | apex1 |
| Gene Description: | apurinic/apyrimidinic endonuclease 1 |
| Aliases: | APE; Apex; HAP1; Ref-1 |
| Human Ortholog Gene ID: | [328] |
| Reviewer Judgement: | TF Gene Candidate |
| Functional Classification: | Transcription Factor Binding: tf co-factor binding |
| Homolog Cluster(s): | 11792 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [1380454] | Other | Human | Strong | EMSA shows that recombinant human Ref1 induces the binding of recombinant Jun protein or Jun extracted from HeLa nuclei to AP-1 DNA elements. This binding is decreased upon immunodepletion of either recombinant Ref1 or HeLa nuclear extracts with anti-Ref1 antibody. | Magdalena Swanson |
| [15084519] | TF PPI | Rat | Strong | Coimmunoprecipitation studies of nuclear extracts from rat pulmonary artery endothelial cells (PAECs) with anti-Ref-1 antibody precipitated p300, CREB, and AFT proteins . | Magdalena Swanson |
| [15674341] | Other | Human | Medium | SDS-PAGE and Western blot analysis shows that recombinant human Ref-1 promotes recombinant human p53 tetramer formation in vitro. | Magdalena Swanson |
| Additional Reviewer Comments: |
Reviewer: Magdalena Swanson Apex1 is a TF candidate. It interacts with transcription factors in coimmunoprecipitation studies. It also aids Jun in binding AP-1 DNA elements in EMSA studies, although Apex1 does not bind these elements itself. SDS-PAGE and Western blot analysis shows that recombinant human Ref-1 promotes recombinant human p53 tetramer formation in vitro. There is no evidence that Apex1 activates transcription directly. |
| DISCUSSION PAGE link for this gene |
|
VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry] |
|
REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here |
| The section below defines information for semantic searching. Please see the help page for more information on this section. |
Facts about Apex1 11792RDF feed
| Gene description | apurinic/apyrimidinic endonuclease 1 + |
| Gene id | 11,792 + |
| Gene judgment | TF Gene Candidate + |
| Gene symbol | apex1 +, APE +, Apex +, HAP1 +, and Ref-1 + |
| Gene taxonomy | Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 11,792 + |
