Aff3 16764
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| Gene ID: | 16764 |
| Gene symbol: | aff3 |
| Gene Description: | af4/fmr2 family, member 3 |
| Aliases: | 3222402O04Rik; A730046J16; LAF-4; Laf4 |
| Human Ortholog Gene ID: | [3899] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | DNA-Binding: non-sequence-specific |
| DBD Protein Group Classification: | Unclassified Structure |
| DBD Protein Group/Family Classification: | Unclassified Structure / AF-4 Protein Family |
| Homolog Cluster(s): | 16764 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [8555498] | Non-specific DNA; Transactivation | Human | Strong | A protein containing AFF3 (LAF4) fused to the GAL4 DNA-binding domain activates UASx5-E1b-CAT in transiently transfected HeLa cells.
In vitro translated AFF3 (LAF-4) binds double-stranded DNA cellulose. | Rob Sladek |
| Additional Reviewer Comments: |
Reviewer: Rob Sladek A protein containing AFF3 (LAF4) fused to the GAL4 DNA-binding domain activates UASx5-E1b-CAT in transiently transfected HeLa cells. In vitro translated AFF3 (LAF-4) binds double-stranded DNA cellulose; however, no studies have attempted to show sequence-specific binding. |
| DISCUSSION PAGE link for this gene |
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Facts about Aff3 16764RDF feed
| Gene description | af4/fmr2 family, member 3 + |
| Gene id | 16,764 + |
| Gene judgment | TF Gene + |
| Gene symbol | aff3 +, 3222402O04Rik +, A730046J16 +, LAF-4 +, and Laf4 + |
| Gene taxonomy | DNA-Binding: non-sequence-specific + |
| Homolog cluster | 16,764 + |
| Protein family | 999 Unclassified Structure/902 AF-4 Protein Family + |
| Protein group | 999 Unclassified Structure + |
