Aes 14797
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| Gene ID: | 14797 |
| Gene symbol: | aes |
| Gene Description: | amino-terminal enhancer of split |
| Aliases: | AL024115; Grg; Grg5 |
| Human Ortholog Gene ID: | [166] |
| Reviewer Judgement: | TF Gene |
| Functional Classification: | Transcription Factor Binding: tf co-factor binding |
| Homolog Cluster(s): | 107986 |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [10660609] | TF PPI | Human | Strong | Using the yeast two-hybrid system, an in vitro GST pull down assay and by in vivo co-immunoprecipitation study in 293 cells, AES is shown to interact with the p65 subunit of the transcription factor NF-kappa B. Transient transfection assays show AES represses gene expression induced by several regulatory molecules including p65. | Amy Ticoll |
| [11416139] | TF PPI | Human | Strong | AR is shown to interact specifically with AES in yeast two-hybrid, mammalian two-hybrid in 293T cells, and coimmunoprecipitation experiments. AES represses AR-dependent luciferase gene expression induced by AR in HeLa cells. In protein-protein pull-down assays, basal transcription factor TFIIE is specifically retained by GST-AES. Experiments conducted with appropriate controls. | Amy Ticoll |
| Additional Reviewer Comments: |
Reviewer: Amy Ticoll AES is shown to interact with other transcription factors using two-hybrid, coimmunoprecipitation, and pull-down assays. Transfection assays show that AES represses gene expression induced by several regulatory molecules. |
| DISCUSSION PAGE link for this gene |
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Facts about Aes 14797RDF feed
| Gene description | amino-terminal enhancer of split + |
| Gene id | 14,797 + |
| Gene judgment | TF Gene + |
| Gene symbol | aes +, AL024115 +, Grg +, and Grg5 + |
| Gene taxonomy | Transcription Factor Binding: tf co-factor binding + |
| Homolog cluster | 107,986 + |
