Abl1 11350
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| Gene ID: | 11350 |
| Gene symbol: | abl1 |
| Gene Description: | c-abl oncogene 1, receptor tyrosine kinase |
| Aliases: | Abl; AI325092; c-Abl; E430008G22Rik; MGC117749 |
| Human Ortholog Gene ID: | |
| Reviewer Judgement: | Indeterminate - There is no evidence for or against this gene's role as a TF |
| Functional Classification: |
Evidence:
| Pubmed ID | Function | Species | Evidence Strength | Reviewer's Comments | Reviewer |
| [16091742] | Transactivation | Human; Mouse | Weak | Activated Abl shown to be involved in transactivation of EGR1 promoter-luc. Promoter deletion constructs show the -480/-235 important. Human 293, U20S inducible lines and murine embryonic fibroblasts used. | Warren Cheung |
| Additional Reviewer Comments: |
Reviewer: Warren Cheung Part of the family of non-receptor tyrosine kinases. No direct TF activity observed, but it is sufficient to activate the EGR1 promoter. |
| DISCUSSION PAGE link for this gene |
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Facts about Abl1 11350RDF feed
| Gene description | c-abl oncogene 1, receptor tyrosine kinase + |
| Gene id | 11,350 + |
| Gene judgment | Indeterminate - There is no evidence for or against this gene's role as a TF + |
| Gene symbol | abl1 +, Abl +, AI325092 +, c-Abl +, E430008G22Rik +, and MGC117749 + |
